| Date | Location | Result | |
| 03/16/22 | Fort Myers, FL | FGCU 95, Detroit Mercy 79 | Box score |
| 03/03/22 | Highland Heights, KY | Northern Ky. 77, Detroit Mercy 59 | Box score |
| 03/01/22 | Detroit, MI | Detroit Mercy 79, Green Bay 62 | Box score |
| 02/26/22 | Detroit, MI | Purdue Fort Wayne 81, Detroit Mercy 78 | Box score |
| 02/24/22 | Detroit, MI | Detroit Mercy 74, Cleveland St. 67 | Box score |
| 02/20/22 | Detroit, MI | Detroit Mercy 80, Wright St. 75 | Box score |
| 02/18/22 | Detroit, MI | Detroit Mercy 60, Northern Ky. 52 | Box score |
| 02/13/22 | Rochester, MI | Oakland 75, Detroit Mercy 59 | Box score |
| 02/11/22 | Youngstown, OH | Youngstown St. 82, Detroit Mercy 69 | Box score |
| 02/09/22 | Moon Township, PA | Detroit Mercy 79, Robert Morris 62 | Box score |
| 02/05/22 | Highland Heights, KY | Detroit Mercy 74, Northern Ky. 68 | Box score |
| 02/04/22 | Fairborn, OH | Wright St. 90, Detroit Mercy 59 | Box score |
| 01/31/22 | Detroit, MI | Detroit Mercy 96, Mich.-Dearborn 51 | Box score |
| 01/27/22 | Detroit, MI | Detroit Mercy 80, UIC 67 | Box score |
| 01/22/22 | Milwaukee, WI | Detroit Mercy 71, Milwaukee 58 | Box score |
| 01/20/22 | Green Bay, WI | Green Bay 70, Detroit Mercy 63 | Box score |
| 01/15/22 | Cleveland, OH | Cleveland St. 72, Detroit Mercy 70 | Box score |
| 01/13/22 | Fort Wayne, IN | Purdue Fort Wayne 62, Detroit Mercy 60 | Box score |
| 01/07/22 | Detroit, MI | Detroit Mercy 85, Milwaukee 60 | Box score |
| 12/19/21 | Detroit, MI | Detroit Mercy 89, Central Mich. 75 | Box score |
| 12/11/21 | Detroit, MI | Detroit Mercy 83, Western Mich. 64 | Box score |
| 12/09/21 | Kent, OH | Kent St. 69, Detroit Mercy 52 | Box score |
| 12/05/21 | Chicago, IL | Detroit Mercy 64, UIC 56 | Box score |
| 12/02/21 | Indianapolis, IN | Detroit Mercy 69, IUPUI 45 | Box score |
| 11/30/21 | Boston, MA | Northeastern 66, Detroit Mercy 56 | Box score |
| 11/27/21 | Hempstead, NY | Hofstra 98, Detroit Mercy 84 | Box score |
| 11/20/21 | Louisville, KY | Louisville 73, Detroit Mercy 67 | Box score |
| 11/17/21 | Starkville, MS | Mississippi St. 77, Detroit Mercy 64 | Box score |
| 11/13/21 | Toledo, OH | Toledo 81, Detroit Mercy 73 | Box score |
| 11/10/21 | Laramie, WY | Wyoming 85, Detroit Mercy 47 | Box score |